Gordon Gribble Tells the Story of the Triterpenoid Project

Triterpenoids and Chemoprevention: A Dartmouth Collaboration For 11 years, Dartmouth chemists Gordon Gribble and Tadashi Honda have collaborated with Dr. Michael Sporn, a professor of pharmacology and toxicology at Dartmouth Medical School, to create drugs that prevent and treat cancer. In 1998, Gribble's lab synthesized CDDO, a synthetic triterpenoid. This compound and one of its derivatives are now in Phase I clinical trials for solid tumors and leukemia. This is a web extra to an article that appeared in the Winter 2006 issue of Dartmouth Medicine Magazine. To read the article, go to: http://dartmed.dartmouth.edu/winter06/html/compound_interest.php